Abstract
Background and aims: Urinary tract infections(UTIs)are one of the most common and the second leading infections, after respiratory tract infections, in women. Currently,various chemical drugs are used to prevent the UTIs.Chemical drugs may cause antibiotic resistance and resistant strains are likely to grow in the long-term treatment with antibiotics.The aim of this study is to investigate the effect of Cornus mas in preventing recurrent UTIs in women aged 15- 45 years referring to Ayatollah Kashani Hospital Clinic Shahrekord.
Methods: This experimental study (Parallel Design and Triple-blind) was conducted on 42 women aged 15-45 years referring to Ayatollah Kashani Hospital Clinic of Shahrekord and diagnosed with chronic cystitis. The exclusion criteria were neurogenic bladder, genitourinary system anatomical abnormalities (hydronephrosis, ureterocele stone,etc),and bacterial resistance. The women were randomly assigned to2groups.At baseline, the women were examined for any functional and anatomical disorders and, if necessary, underwent ultrasound. After the current UTIs were treated and the women clinically recovered, one group was administered with Cornus mas tablet 500mg and another group administered with placebo for6months.All the women were followed up for6 months. Every 2 months, the patients were clinically examined and their urine cultures were investigated for the clinical signs of cystitis. As the symptoms of the UTIs occur, the patients were recommended to refer for repeated urine culture. All patients (42 women)completed the study.
Results: In our study, nosignificant difference was observed between the groups in terms of recurrent UTI recurrence, although there were differences(P>0.005).Positive urine culture in Cornusmas group was19% and in placebo was33.4%. In terms of dysuria in 6 months and the second time there was significant difference between placebo and Cornus mas (P=0.004) Dysuria in Cornusmas group was14.2% and in placebo was56.2%.
Conclusion: Cornusmas can decrease dysuria and frequent urination in patients with recurrent UTIs, So it can be used in the treatment of these patients.