Abstract
Background and aims: Leptin is a hormone known to control appetite and body weight. The leptin Levels in obese animals are always more than animals with normal size. A wide variety of methods have been offered to treat obesity of which herbal therapy is considered as one of these methods. The aim of this study was to investigate the effect of ethanolic extract of Asian Red Ginseng on leptin serum level in male wistar rats.
Methods: In this “in vitro” experimental study, 30 adult male wistar rats were randomly divided into 5 groups equally: control (no drug), SHAM (received 1ml of physiology serrum), Interventional group 1 (received 20mg/kg ethanolic extract of Asian red ginseng), Interventional group 2 (received 40mg/kg) and Interventional group 3 (receiver 80mg/kg). The extract was injected intraperitoneally for 20 days. On the twentieth day, blood samples were collected. Dataset of experiments were collected and analyzed with Graphpad Prism 5 software. Data were analyzed using one-way ANOVA and P<0.05 was considered significant.
Results: The dose-dependent injection of the ethanolic extract of Asain Red Ginseng root did not show a significant effect on leptin hormone serum level, but it showed a significant decrease in food intake compared to the control group.
Conclusion: The ethanolic extract of Asian red ginseng root does not reduce the serum level of leptin hormone.