Quinic acid through mitigation of oxidative stress in the hippocampus exerts analgesic effect in male mice

Document Type : Original Article

Authors

1 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran

2 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract

Background and aims: Pain is a human societies problems that has always had a lot of attention to control. However, some patients became resistance to analgesic effect of common analgesics. A main goal of the researches on the field of pain is to find effective medications with less side effects. In this regards, natural derivatives of medicinal plants are under considering of researchers. It has been determined that oxidative stress involved in the pathophysiology of pain. The aim of this study is to investigate the analgesic effect of quinic acid considering its possible antioxidative effects in male mice.
Methods: In this experimental study, 40 male mice were divided into 4 groups (N=10) received normal saline (1 ml/kg), dexamethasone (5 mg/ kg), quinic acid (QA) (10 mg/kg) and QA (50 mg/kg) for 7 constant days via intraperitoneal route. Then, the pain response was assessed using hot plate test. Finally, mice were euthanized and hippocampi dissected out. The levels of malondialdehyde (MDA), nitrite as well as antioxidant capacity were measure in the hippocampus.
Results: The results showed that QA significantly increased the duration of delay in pain response to heat. Furthermore, QA significantly increased the antioxidant capacity as well as decreased the levels of MDA and nitrite in the hippocampus.
Conclusion: we concluded that QA, partially at least, through mitigation of oxidative stress (increased the antioxidant capacity as well as decreased the levels of MDA and nitrite) exerts analgesic effect in the hot plate test in male mice.

Keywords

References

1.Balkema K, Claytor K, Clevenger K, Conn K, Conner S, Freisner I. Medical surgical nursing certification. Philadel-phia. Lippincott; 2012.
2.Saarto T, Wiffen PJ. Antidepressants for neuropathic pain: a Cochrane review. Journal of Neurology, Neurosurgery & Psychiatry. 2010;81(12):1372-3.
3.Smeltzer S. Bare, BG, Hinkle, JL, & Cheever, KH Brunner & Suddarth’s. Textbook of Medical-Surgical Nursing 12th edition Philadelphia: Lippincott Williams & Wilkins Willett WC Non modifiable factors in causation of breast cancer 4th edition Philadelphia: Lippincott Williams and Wilkins. 2010:248-90.
4.Guyton AC, Hall JE. Medical physiology. Gökhan N, Çavuşoğlu H (Çeviren). 2006;3.
5.Foss JF. A review of the potential role of methylnaltrexone in opioid bowel dysfunction. The American journal of surgery. 2001;182(5):S19-S26.
6.Taha R, Blaise GA. Update on the pathogenesis of complex regional pain syndrome: role of oxidative stress. Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 2012;59(9):875-81.
7.Valerio DA, Georgetti SR, Magro DA, Casagrande R, Cunha TM, Vicentini FT, et al. Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production. Journal of Natural Products. 2009;72(11):1975-9.
8.Mehrotra A, Shanbhag R, Chamallamudi MR, Singh VP, Mudgal J. Ameliorative effect of caffeic acid against inflammatory pain in rodents. European Journal of Pharmacology. 2011;666(1-3):80-6.
9.Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaiee A. Pesticides and oxidative stress: a review. Medical Science Monitor. 2004;10(6):RA141-RA7.
10.Halliwell B. Oxidative stress and neurodegeneration: where are we now? Journal of neurochemistry. 2006;97(6):1634-58.
11.Sepehri G, Sheibani V, Pahlavan Y, Afarinesh Khaki M, Esmail Pour Bezenjani K, Pahlavan B. Effect of interacerebroventricular injection of aqueous extract of Origanum vulgare L. ssp. viride on pain threshold in male rats. Journal of Ardabil University of Medical Sciences. 2011;11(1):52-8.
12.Liu L, Liu Y, Zhao J, Xing X, Zhang C, Meng H. Neuroprotective effects of D-(-)-quinic acid on aluminum chloride-induced dementia in rats. Evidence-Based Complementary and Alternative Medicine. 2020;2020.
13.Oh JH, Karadeniz F, Lee JI, Seo Y, Kong CS. Protective effect of 3, 5 dicaffeoyl epi quinic acid against UVB induced photoaging in human HaCaT keratinocytes. Molecular medicine reports. 2019;20(1):763-70.
14.Basnet P, Matsushige K, Hase K, Kadota S, Namba T. Four di-O-caffeoyl quinic acid derivatives from propolis. Potent hepatoprotective activity in experimental liver injury models. Biological and Pharmaceutical Bulletin. 1996;19(11):1479-84.
15.Pulido R, Bravo L, Saura-Calixto F. Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay. Journal of agricultural and food chemistry. 2000;48(8):3396-402.
16.Jang S-A, Park DW, Kwon JE, Song HS, Park B, Jeon H, et al. Quinic acid inhibits vascular inflammation in TNF-α-stimulated vascular smooth muscle cells. Biomedicine & Pharmacotherapy. 2017;96:563-71.
17.Smoker MP, Mackie K, Lapish CC, Boehm II SL. Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice. Drug and alcohol dependence. 2019;199:106-15.
18.Mbodji K, Torre S, Haas V, Déchelotte P, Marion-Letellier R. Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model. Clinical Nutrition. 2011;30(5):672-7.
19.Srivastava A, Shivanandappa T. Hepatoprotective effect of the root extract of Decalepis hamiltonii against carbon tetrachloride-induced oxidative stress in rats. Food chemistry. 2010;118(2):411-7.
20.Namıduru E, Tarakçoğlu M, Namıduru M, Kocabaş R, Erbağcı B, Meram I, et al. Increased serum nitric oxide and malondialdehyde levels in patients with acute intestinal amebiasis. Asian Pacific journal of tropical biomedicine. 2011;1(6):478-81.
21.Kim HK, Park SK, Zhou J-L, Taglialatela G, Chung K, Coggeshall RE, et al. Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain. 2004;111(1-2):116-24.
22.Luo Z, Harada T, London S, Gajdusek C, Mayberg MR. Antioxidant and iron-chelating agents in cerebral vasospasm. Neurosurgery. 1995;37(6):1154-9.
23.Cheraghi J, Valadi A. Effects of anti-nociceptive and anti-inflammatory component of limonene in herbal drugs. Iranian Journal of Medicinal and Aromatic Plants Research. 2010;26(3):415-22.
24.Herrmann KM. The shikimate pathway: early steps in the biosynthesis of aromatic compounds. The Plant Cell. 1995;7(7):907.
25.Morteza-Semnani K, Saeedi M, Hamidian M, Vafamehr H, Dehpour AR. Anti-inflammatory, analgesic activity and acute toxicity of Glaucium grandiflorum extract. Journal of ethnopharmacology. 2002;80(2-3):181-6.
26.Zafir A, Banu N. Modulation of in vivo oxidative status by exogenous corticosterone and restraint stress in rats. Stress. 2009;12(2):167-77.
27.Czerska M, Mikołajewska K, Zieliński M, Gromadzińska J, Wąsowicz W. Today’s oxidative stress markers. Medycyna pracy. 2015;66(3).
28.Mirzaei F, Khazaei M. Role of nitric oxide in biological systems: a systematic review. Journal of Mazandaran University of Medical Sciences. 2017;27(150):192-222.
29.Mehanna MM, Domiati S, Chmaisse HN, El Mallah A. Antinociceptive effect of tadalafil in various pain models: involvement of opioid receptors and nitric oxide cyclic GMP pathway. Toxicology and applied pharmacology. 2018;352:170-5.
30.Matsushige K, Basnet P, Kadota S, Namba T. Potent free radical scavenging activity of dicaffeoyl quinic acid derivatives from propolis. J Trad Med. 1996;13:217-28.
Future Natural Products
Volume 7, Issue 2
Summer and Autumn 2021
Pages 1-11

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