The effects of Urtica dioica extract on lipid profile, Insulin Resistance index and liver histology in Polycystic Ovary Syndrome-induced Wistar rats

Document Type : Original Article


1 Professor of Physiology, Department of Biological Science, Faculty of Science, Urmia University, Urmia, Iran.

2 Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.

3 MSc Student in animal physiology, Department of Animal Biology, Faculty of Sciences, Urmia University, Urmia, Iran.

4 MSc Student in cellular and Developmental Biology, Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.

5 MSc in cellular and Developmental Biology, Laboratories’ Animal Center & Cellular And Molecular Research Laboratory, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.


Background and aims: Urtica dioica as a medicinal herb due to its anti-inflammatory, antioxidant and hypoglycemic effects, improve type 2 diabetes and decrease inflammation, fibrosis and necrosis as the signs of Nonalcoholic steatohepatitis. Polycystic Ovary Syndrome (PCOS) as the most important factor of infertility has an overlap of 30 % to 60% with liver disorders. Hence, the Urtica dioica moderator effect on liver function in PCOS rats was examined. Methods: In this experimental study 144 adult Wistar rats were divided into control, PCOS and nettle-treated groups. The group PCOS was injected subcutaneously 2 mg estradiol valerate, after 60 days and confirmed polycystic, the experimental group was injected intraperitoneally the Urtica dioica extract doses (150,250, 450 mg/kg BW). After 21 days, rats were anesthetized by chloroform; blood samples and livers were collected for histological and serological evaluation. Data were analyzed using instat3 via ANOVA one-way and p


Main Subjects

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