A review of therapeutic and non-therapeutic properties of sea buckthorn

Document Type : Review Article

Authors

1 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, I.R. Iran

2 Shahrekord University of Medical Sciences; Shahrekord, I.R. Iran

Abstract

Background and aims: Sea buckthorn (Hippophae rhamnoides L.) is a deciduous plant and has highly variable type and size, from small shrubs to medium-sized trees, traditionally growing in Tibet and currently all over the world especially in Europe and Asia. This study aimed to overview some of therapeutic and non-therapeutic properties of SBT and its potential benefits and side effects in order to open up a clear understanding for further detailed study in this regard. Methods: This review article was carried out by searching studies in Web of Science, Google Scholar, PubMed and ScienceDirect. The search terms were “Sea buckthorn”, “Sea buckthorn” and “hippophae”, “therapeutic”, “non-therapeutic”. Results: Various studies have shown that sea buckthorn plays a role in the treatment of cardiovascular disease, liver fibrosis, skin diseases (eczema, acne,), arthritis, vaginal atrophy, dry eye. This herb has anti- inflammatory, anti-constipation, antioxidant, anti-aging, anti-cancer, anti-stress, antidepressant and antiproliferative effects. Besides, it enjoys some non-therapeutic properties including nutritive values (a good source of vitamin C, E, omega 3, 6, 7), oral and dental health care value and cosmetic value (in the industry of cosmetics: cream, shampoo, jellies, and etc.). Conclusion: sea buckthorn is widely used for therapeutic and non-therapeutic purposes that trigger its significant value. Various combinations and numerous medicinal properties of its berries, fruits, extract, pulp, seed oil, leaves demand further and more studies about the other useful and unknown properties of this multifunctional plant.

Keywords

Main Subjects


1. Suryakumar G, Gupta A. Medicinal and therapeutic potential of SBT (Hippophae rhamnoides L.). J Ethnopharmacol. 2011; 138(2): 268-78.
2. Khan IA, Abourashed EA. Leung's Encyclopedia of Common Natural Ingredients: Used in Food, Drugs and Cosmetics. 3rd ed: USA: John Wiley & Sons Pub; 2009.
3. Grieve M. A modern herbal: the medicinal, culinary, cosmetic and economic properties, cultivation and folk-lore of herbs, grasses, fungi, shrubs, & trees with all their modern scientific uses. Philadelphia: Courier Corporation; 1971.
4. Shinde S, Aniket K, Kulaga T, Licamele JD, Tonkovich AL. Omega 7 rich compositions and methods of isolating omega 7 fatty acids. United States patent US WO 2013075116 A2. 2013.
5. Guliyev VB, Gul M, Yildirim A. Hippophae rhamnoides L.: chromatographic methods to determine chemical composition, use in traditional medicine and pharmacological effects. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 812(1-2): 291-307.
6. Grey C, Widén C, Adlercreutz P, Rumpunen K, Duan R-D. Antiproliferative effects of SBT (Hippophae rhamnoides L.) extracts on human colon and liver cancer cell lines. Food Chem. 2010; 120(4): 1004-10.
7. Guan M, Zhou Y, Zhu QL, Liu Y, Bei YY, Zhang XN, et al. N-trimethyl chitosan nanoparticle-encapsulated lactosyl-norcantharidin for liver cancer therapy with high targeting efficacy. Nanomedicine. 2012; 8(7): 1172-81.
8. Zeb A. Anticarcinogenic potential of lipids from Hippophae--evidence from the recent literature. Asian Pac J Cancer Prev. 2006; 7(1): 32-5.
9. Larmo PS, Yang B, Hyssala J, Kallio HP, Erkkola R. Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: a randomized, double-blind, placebo-controlled study. Maturitas. 2014; 79(3): 316-21.
10. Larmo PS, Jarvinen RL, Setala NL, Yang B, Viitanen MH, Engblom JR, et al. Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye. J Nutr. 2010; 140(8): 1462-8.
11. Xu Y-J, Kaur M, Dhillon RS, Tappia PS, Dhalla NS. Health benefits of SBT for the prevention of cardiovascular diseases. J Funct Foods. 3(1): 2-12.
12. Maheshwari DT, Yogendra Kumar MS, Verma SK, Singh VK, Singh SN. Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves. Food Chem Toxicol. 2011; 49(9): 2422-8.
13. Varshneya C, Kant V, Mehta M. Total phenolic contents and free radical scavenging activities of different extracts of seabuckthorn (Hippophae rhamnoides L.) pomace without seeds. Int J Food Sci Nutr. 2012; 63(2): 153-9.
14. Battistoni A, Mazzetti AP, Petruzzelli R, Muramatsu M, Federici G, Ricci G, et al. Cytoplasmic and periplasmic production of human placental glutathione transferase in Escherichia coli. Protein Expr Purif. 1995; 6(5): 579-87.
15. Geetha S, Sai Ram M, Singh V, Ilavazhagan G, Sawhney RC. Anti-oxidant and immunomodulatory properties of seabuckthorn (Hippophae rhamnoides L.) an in vitro study. J Ethnopharmacol. 2002; 79(3): 373-8.
16. Negi PS, Chauhan AS, Sadia GA, Rohnishree YS, Ramteke RS. Antioxidant and antibacterial activities of various seabuckthorn (Hippophae rhamnoides L.) seed extracts. Food Chem. 2005; 92(1): 119-24.
17. Kim JS, Kwon YS, Sa YJ, Kim MJ. Isolation and identification of sea buckthorn (Hippophae rhamnoides L.) phenolics with antioxidant activity and alpha-glucosidase inhibitory effect. J Agric Food Chem. 2011; 59(1): 138-44.
18. Ercisli S, Orhan E, Ozdemir O, Sengul M. The genotypic effects on the chemical composition and antioxidant activity of SBT (Hippophae rhamnoides L.) berries grown in Turkey. Sci Hortic. 2007; 115(1): 27-33.
19. Kumar MS, Dutta R, Prasad D, Misra K. Subcritical water extraction of antioxidant compounds from Seabuckthorn (Hippophae rhamnoides L.) leaves for the comparative evaluation of antioxidant activity. Food Chem. 2011; 127(3): 1309-16.
20. Padwad Y, Ganju L, Jain M, Chanda S, Karan D, Kumar Banerjee P, et al. Effect of leaf extract of Sea buckthorn on lipopolysaccharide induced inflammatory response in murine macrophages. Int Immunopharmacol. 2006; 6(1): 46-52.
21. Tiwari S, Bala M. Hippophae leaves prevent immunosuppression and inflammation in 60 Co-γ-irradiated mice. Phytopharmacology. 2011; 1(3): 36-48.
22. Wang ZY, Luo XL, He CP. Management of burn wounds with Hippophae rhamnoides oil. Nan Fang Yi Ke Da Xue Xue Bao. 2006; 26(1): 124-5.
23. Upadhyay NK, Kumar R, Mandotra SK, Meena RN, Siddiqui MS, Sawhney RC, et al. Safety and healing efficacy of Sea buckthorn (Hippophae rhamnoides L.) seed oil on burn wounds in rats. Food Chem Toxicol. 2009; 47(6): 1146-53.
24. Gupta A, Kumar R, Pal K, Singh V, Banerjee PK, Sawhney RC. Influence of sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in rats. Mol Cell Biochem. 2006; 290(1-2): 193-8.
25. Ito H, Asmussen S, Traber DL, Cox RA, Hawkins HK, Connelly R, et al. Healing efficacy of sea buckthorn (Hippophae rhamnoides L.) seed oil in an ovine burn wound model. Burns. 2014; 40(3): 511-9.
26. Varshney A. Prophylactic efficacies of Seabuckthorn (Hippophae rhamnoides L.) oil vis-à-vis other standard drugs for gastric ulceration and erosions in dogs. Indian J Vet Surg. 2011; 32(2): 156-157.
27. Xing J, Yang B, Dong Y, Wang B, Wang J, Kallio HP. Effects of sea buckthorn (Hippophae rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. Fitoterapia. 2002; 73(7-8): 644-50.
28. Batool F, Kamal A, Sattar M, Shah AH, Ahmed SD, Saify ZS, et al. Evaluation of antidepressant-like effects of aqueous extract of sea buckthorn (Hippophae rhamnoides L. ssp. turkestanica) fruits in experimental models of depression. Pak. J. Bot. 2011; 43(3): 1595-9.
29. Rafieian-Kopaei M, Baradaran A, Rafieian M. Plants antioxidants: From laboratory to clinic. J Nephropathol. 2013; 2(2): 152-3.
30. Ogino Y, Osada K, Nakamura S, Ohta Y, Kanda T, Sugano M. Absorption of dietary cholesterol oxidation products and their downstream metabolic effects are reduced by dietary apple polyphenols. Lipids. 2007; 42(2): 151-61.
31. Eccleston C, Baoru Y, Tahvonen R, Kallio H, Rimbach GH, Minihane AM. Effects of an antioxidant-rich juice (sea buckthorn) on risk factors for coronary heart disease in humans. J Nutr Biochem. 2002; 13(6): 346-54.
32. Purushothaman J, Suryakumar G, Shukla D, Malhotra AS, Kasiganesan H, Kumar R, et al. Modulatory effects of seabuckthorn (Hippophae rhamnoides L.) in hypobaric hypoxia induced cerebral vascular injury. Brain Res Bull. 2008; 77(5): 246-52.
33. Goel HC, Prasad J, Singh S, Sagar RK, Kumar IP, Sinha AK. Radioprotection by a herbal preparation of Hippophae rhamnoides L., RH-3, against whole body lethal irradiation in mice. Phytomedicine. 2002; 9(1): 15-25.
34. Osada K, Kodama T, Yamada K, Nakamura S, Sugano M. Dietary oxidized cholesterol modulates cholesterol metabolism and linoleic acid desaturation in rats fed high-cholesterol diets. Lipids. 1998; 33(8): 757-64.
35. Gao Z, Zhang C, Jin L, Yao W. Efficacy of SBT Therapy in Patients with Nonalcoholic Fatty Liver Disease. Chin Med J. 2014; 5(4): 223-30.
36. Hsu YW, Tsai CF, Chen WK, Lu FJ. Protective effects of sea buckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2009; 47(9): 2281-8.
37. Gao ZL, Gu XH, Cheng FT, Jiang FH. Effect of sea buckthorn on liver fibrosis: a clinical study. World J Gastroenterol. 2003; 9(7): 1615-7.
38. Geetha S, Jayamurthy P, Pal K, Pandey S, Kumar R, Sawhney RC. Hepatoprotective effects of SBT (Hippophae rhamnoides L.) against carbon tetrachloride induced liver injury in rats. J Sci Food Agric. 2008; 88(9): 1592-7.
39. Yang B, Kalimo KO, Mattila LM, Kallio SE, Katajisto JK, Peltola OJ, et al. Effects of dietary supplementation with SBT (Hippophae rhamnoides L.) seed and pulp oils on atopic dermatitis. J Nutr Biochem. 1999; 10(11): 622-30.
40. Puupponen-Pimia R, Nohynek L, Meier C, Kahkonen M, Heinonen M, Hopia A, et al. Antimicrobial properties of phenolic compounds from berries. J Appl Microbiol. 2001; 90(4): 494-507.
41. Jain M, Ganju L, Katiyal A, Padwad Y, Mishra KP, Chanda S, et al. Effect of Hippophae rhamnoides leaf extract against Dengue virus infection in human blood-derived macrophages. Phytomedicine. 2008; 15(10): 793-9.
42. Guliyev VB, Gul M, Yildirim A. Hippophae rhamnoides L.: chromatographic methods to determine chemical composition, use in traditional medicine and pharmacological effects. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 812(1-2): 291-307.
43. Bahmani M, Rafieian-Kopaei M, Avijgan M. Ethnobotanical studies of medicinal plants used by Kurdish owners in south range of Ilam province, west of Iran. Am-Euras J Agric Environ Sci. 2012; 12(9): 1128-33.
44. Rafieian-Kopaei M. Medicinal plants and the human needs. J Herb Med Pharmacol. 2012; 1(1): 1-2.
45. Johansson AK, Korte H, Yang B, Stanley JC, Kallio HP. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem. 2000; 11(10): 491-5.
46. Bal LM, Meda V, Naik SN, Satya S. SBT berries: A potential source of valuable nutrients for nutraceuticals and cosmoceuticals. Food Res Int. 44(7): 1718-27.
47. Dembitsky VM, Poovarodom S, Leontowicz H, Leontowicz M, Vearasilp S, Trakhtenberg S, et al. The multiple nutrition properties of some exotic fruits: biological activity and active metabolites. Food Res Int. 2011; 44(7): 1671-701.
48. Gutzeit D, Baleanu G, Winterhalter P, Jerz G. Vitamin C content in sea buckthorn berries (Hippophae rhamnoides L. ssp. rhamnoides) and related products: a kinetic study on storage stability and the determination of processing effects. J Food Sci. 2008; 73(9): 615-20.
49. Tiitinen KM, Yang B, Haraldsson GG, Jonsdottir S, Kallio HP. Fast analysis of sugars, fruit acids, and vitamin C in sea buckthorn (Hippophae rhamnoides L.) varieties. J Agric Food Chem. 2006; 54(7): 2508-13.
50. Shah AH, Ahmed D, Sabir M, Arif S, Khaliq I, Batool F. Biochemical and nutritional evaluations of SBT (Hyppophae rhamnoides L. Spp. Turkestanica) from different locations of Pakistan. Pak J Bot. 2007; 39(6): 2059-65.
51. Ganju L, Padwad Y, Singh R, Karan D, Chanda S, Chopra MK, et al. Anti-inflammatory activity of Seabuckthorn (Hippophae rhamnoides L.) leaves. Int Immunopharmacol. 2005; 5(12): 1675-84.
52. Suleyman H, Gumustekin K, Taysi S, Keles S, Oztasan N, Aktas O, et al. Beneficial effects of Hippophae rhamnoides L. on nicotine induced oxidative stress in rat blood compared with vitamin E. Biol Pharm Bull. 2002; 25(9): 1133-6.
53. Saggu S, Divekar HM, Gupta V, Sawhney RC, Banerjee PK, Kumar R. Adaptogenic and safety evaluation of seabuckthorn (Hippophae rhamnoides L.) leaf extract: a dose dependent study. Food Chem Toxicol. 2007; 45(4): 609-17.
54. Kumar P. Ethno medicinal plants used for oral health care in India. Justicia. 2014; 6: 7.
55. Janick J, Whipkey A. Product development of SBT. Trends in new crops and new uses. USA: ASHS Press, Alexandria; 2002: 393-8.
56. Khan BA, Akhtar N, Braga VA. Anti-Aging Effects of Hippophae rhamnoides Emulsion on Human Skin. Trop Pharm Res. 2013; 11(6): 955-62.
57. Giri R, Sahoo D, Panda S, Swain S, Kanungo V, Patro S, et al. Lipid lowering activity of the fruit juice of Hippophae rhamnoides L. (Sea buckthorn) in hyperlipidemic models of Wistar albino rats. Pharmacologyonline. 2009; 1: 1277-83.
58. Akhtar N, Khan BA, Mahmood T, Parveen R, Qayum M, Anwar M, et al. Formulation and evaluation of antisebum secretion effects of sea buckthorn w/o emulsion. J Pharm Bioallied Sci. 2010; 2(1): 13-7.
59. Hwang IS, Kim JE, Choi SI, Lee HR, Lee YJ, Jang MJ, et al. UV radiation-induced skin aging in hairless mice is effectively prevented by oral intake of sea buckthorn (Hippophae rhamnoides L.) fruit blend for 6 weeks through MMP suppression and increase of SOD activity. Int J Mol Med. 2012; 30(2): 392-400.